SOD Cu-Zn/SOD1: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of SOD Cu-Zn/SOD1. The page also collects GeneMedi's different modalities and formats products for SOD Cu-Zn in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the SOD Cu-Zn target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Transmembrane Protein.
The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. In addition, this protein contains an antimicrobial peptide that displays antibacterial, antifungal, and anti-MRSA activity against E. coli, E. faecalis, S. aureus, S. aureus MRSA LPV+, S. agalactiae, and yeast C. krusei. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2020]
| Target ID | GM-T22977 |
| Target Name | SOD Cu-Zn |
| Gene ID | 6647,20655,24786,574096,403559,101091804,281495,100033855 |
| Gene Symbol and Synonyms | ALS,ALS1,B430204E11Rik,Cu/Zn-SOD,CuZnSOD,HEL-S-44,homodimer,hSod1,Ipo-1,Ipo1,IPOA,SOD,Sod-1,SOD1,SOD1L1,SODC,STAHP |
| Uniprot Accession | P00441,P07632,Q8HXQ0,Q8WNN6,P00442,P00443 |
| Uniprot Entry Name | SODC_HUMAN,SODC_MACMU,SODC_RAT,SODC_CANLF,SODC_BOVIN,SODC_HORSE |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Lung Cancer, ALS |
| Gene Ensembl | ENSG00000142168 |
| Target Classification | N/A |
Pre-made anti-SOD Cu-Zn inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-SOD Cu-Zn benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-SOD Cu-Zn mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
| Antibody Name | Species | Format | Classified by tag | Detail |
| Anti-SOD Cu-Zn/SOD1 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Multi-species SODC/ SOD Cu-Zn/ SOD1 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SOD Cu-Zn/SOD1 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
| Products Name | Species | Expression Platform | Detail |
| SOD Cu-Zn/SOD1 VLP (virus-like particle) | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Products Developing |
Pre-made SOD1 viral vector in GM Promise-ORFTM
| Cat No. | Products name | NM ID | Species | Type | Detail |
| vGMLP000506 | human SOD1 Lentivirus particle | NM_000454 | Human | Lentivirus particle | Detail |
| pGMLP000506 | human SOD1 Lentivirus plasmid | NM_000454 | Human | Lentivirus plasmid | Detail |
| vGMAP000004 | Human SOD1 Adenovirus particle | BC001034 | Human | Adenovirus particle | Detail |
| pGMAP000004 | Human SOD1 Adenovirus plasmid | BC001034 | Human | Adenovirus plasmid | Detail |
| pGMLPm000209 | mouse Sod1 Lentivirus plasmid | NM_011434 | Mouse | Lentivirus plasmid | Detail |
| vGMLPm000209 | mouse Sod1 Lentivirus particle | NM_011434 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.