HBB: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of HBB. The page also collects GeneMedi's different modalities and formats products for HBB in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the HBB target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Introcelluar Protein.
The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]
| Target ID | GM-T31825 |
| Target Name | HBB |
| Gene ID | 3043,715559 |
| Gene Symbol and Synonyms | beta-globin,CD113t-C,ECYT6,HBB |
| Uniprot Accession | P68871,P02026 |
| Uniprot Entry Name | HBB_HUMAN,HBB_MACMU |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Malignant neoplasm of bladder, Complications of kidney transplant, IgA glomerulonephritis |
| Gene Ensembl | ENSG00000244734 |
| Target Classification | N/A |
Pre-made anti-HBB inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-HBB monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-HBB mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
| Antibody Name | Species | Format | Classified by tag | Detail |
| Anti-HBB monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | Therapeutics Target antibody | Detail |
Recombinant multi-species HBB/ CD113t-C/ ECYT6 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HBB protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
| Products Name | Species | Expression Platform | Detail |
| HBB protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made HBB viral vector in GM Promise-ORFTM
| Cat No. | Products name | NM ID | Species | Type | Detail |
| pGMAP000026 | Human HBB Adenovirus plasmid | BC007075 | Human | Adenovirus plasmid | Detail |
| vGMAP000026 | Human HBB Adenovirus particle | BC007075 | Human | Adenovirus particle | Detail |
| vGMLP000401 | human HBB Lentivirus particle | BC007075 | Human | Lentivirus particle | Detail |
| pGMLP000401 | human HBB Lentivirus plasmid | BC007075 | Human | Lentivirus plasmid | Detail |
| pGMLPm003402 | mouse Hbb-bt Lentivirus plasmid | NM_008220.5 | Mouse | Lentivirus plasmid | Detail |
| pGMLPm004294 | mouse Hbb-bs Lentivirus plasmid | NM_001201391.1 | Mouse | Lentivirus plasmid | Detail |
| vGMLPm003402 | mouse Hbb-bt Lentivirus particle | NM_008220.5 | Mouse | Lentivirus particle | Detail |
| vGMLPm004294 | mouse Hbb-bs Lentivirus particle | NM_001201391.1 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.