NR4A1: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of NR4A1. The page also collects GeneMedi's different modalities and formats products for NR4A1 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the NR4A1 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Introcelluar Protein.
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
| Target ID | GM-T41119 |
| Target Name | NR4A1 |
| Gene ID | 3164,15370,79240,696797,403897,101097902,528390,100061353 |
| Gene Symbol and Synonyms | Gfrp,GFRP1,Hbr-1,Hbr1,HMR,N10,NAK-1,NGFI-B,NGFIB,NP10,NR4A1,NUR77,NUR77-1,NUR77-2,TIS1,TR3 |
| Uniprot Accession | P22736,P22829,P51666,Q0V8F0 |
| Uniprot Entry Name | NR4A1_HUMAN,NR4A1_RAT,NR4A1_CANLF,NR4A1_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Prostate Cancer |
| Gene Ensembl | ENSG00000123358 |
| Target Classification | N/A |
Pre-made anti-NR4A1 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-NR4A1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-NR4A1 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
| Antibody Name | Species | Format | Classified by tag | Detail |
| Anti-NR4A1 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | Therapeutics Target antibody | Detail |
Recombinant multi-species NR4A1/ GFRP1/ HMR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NR4A1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
| Products Name | Species | Expression Platform | Detail |
| NR4A1 protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made NR4A1 viral vector in GM Promise-ORFTM
| Cat No. | Products name | NM ID | Species | Type | Detail |
| vGMLP000089 | human NR4A1 Lentivirus particle | NM_173157 | Human | Lentivirus particle | Detail |
| pGMLP000089 | human NR4A1 Lentivirus plasmid | NM_173157 | Human | Lentivirus plasmid | Detail |
| pGMLV000800 | house mouse Nr4a1 Lentivirus plasmid | NM_010444.2 | House Mouse | Lentivirus plasmid | Detail |
| pGMLPm004456 | mouse Nr4a1 Lentivirus plasmid | NM_010444 | Mouse | Lentivirus plasmid | Detail |
| vGMLV000800 | house mouse Nr4a1 Lentivirus particle | NM_010444.2 | House Mouse | Lentivirus particle | Detail |
| vGMLPm004456 | mouse Nr4a1 Lentivirus particle | NM_010444 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.