Subtitle: High-Purity Substrates, Market Intelligence, and Reagents for Epigenetic Modulator Screening.
TarMart Solution Ecosystem & Related Targets
H4C12 is a replication-dependent histone gene that encodes the canonical 102-amino-acid histone H4 protein. Because multiple histone H4 genes encode the exact same amino acid sequence (UniProt P62805), H4 paralogs cannot be distinguished at the protein level. H4C12 itself is not an enzyme, but rather the essential structural substrate for epigenetic writers (HATs, HMTs), erasers (HDACs, KDMs), and readers (Bromodomains).
Comprehensive reagent toolkit for Epigenetic drug discovery utilizing Histone H4. Select your modality below:
| Component / Network | Product Description | Product Link |
|---|---|---|
| Antigen / Substrate | H4C12 (Histone H4) Recombinant Protein High purity (>95%), Endotoxin <1EU/ug. Sequence Verified unmodified substrate for enzymatic assays. |
View H4C12 Products |
| Gene Delivery | H4C12 Promise-ORF Full-length ORF for stable expression and nucleosome assembly studies. |
View H4C12 Products |
| Benchmark Ab | Anti-Histone H4 (Pan and PTM-specific) Recombinant positive controls for Acetyl-H4 and Methyl-H4 detection. |
View H4C12 Products |
| Validator | H4C12 siRNA Set For specific transcript knockdown verification (the only way to distinguish H4C12 from other H4 paralogs). |
View H4C12 Products |
| Related Target A | HDAC1 Histone deacetylase 1; key epigenetic eraser that modifies Histone H4. |
View HDAC1 Products |
| Related Target B | BRD4 Bromodomain-containing protein 4; critical epigenetic reader of acetylated Histone H4. |
View BRD4 Products |
| Critical Assay Challenge | The TarMart Advantage (Technical Spec) |
|---|---|
| Distinguishing H4 Paralogs | H4 proteins are identical (UniProt P62805). TarMart provides highly specific H4C12 siRNA to target the unique transcript sequence. |
| Background PTMs in Enzymatic Assays | E. coli expressed Recombinant Histone H4 guarantees an unmodified, zero-background substrate for HAT/HMT screening. |
| Lack of Controls for Reader Assays | Sequence Verified, precisely modified (e.g., synthetically acetylated) peptides and proteins available for Bromodomain binding assays. |
| False Positives in Chromatin IP | Strictly validated Anti-H4 antibodies with cross-reactivity panels against H2A, H2B, and H3 to ensure absolute specificity. |
Live H4C12 Epigenetics R&D Tracker
Market data and epigenetic research evolve rapidly. Access the latest global pipeline status directly:
- ➤ View Active Clinical Trials (HDAC Inhibitors)
- ➤ Latest Epigenetic Research
- ➤ Recent Patent Filings
Global Clinical Landscape & Future Outlook
H4C12 is not a direct therapeutic target with its own named clinical pipeline. Instead, the canonical Histone H4 protein it encodes is the foundational substrate driving the multi-billion dollar epigenetic therapeutics market. The pharmaceutical industry is heavily invested in targeting the enzymes that modify Histone H4 (methyltransferases, acetyltransferases, and deacetylases) rather than the histone itself. As first-generation epigenetic drugs (like pan-HDAC inhibitors) reach maturity, the next wave of R&D is shifting toward targeted protein degradation (PROTACs) of epigenetic readers and highly selective mutant-specific epigenetic modulators. Verifiable H4C12-specific therapeutic evidence is currently unavailable, making it critical to focus R&D efforts on its role as an assay substrate and biomarker.
Competitive Modality & Indication Snapshot
Connecting market trends to assay needs utilizing Histone H4 substrates.
| Modality | Target Class | Key Indications | Critical Assay Need (Why TarMart?) |
|---|---|---|---|
| Small Molecule | HDAC Inhibitors (Erasers) | Hematological Malignancies | In vitro Deacetylation Assay (Requires high-purity, pre-acetylated H4 substrate) |
| PROTAC / Degrader | BET Family / BRD4 (Readers) | Solid Tumors, Lymphoma | Binding/Displacement Assay (Requires Sequence Verified Histone H4) |
| Small Molecule | HAT / HMT Inhibitors (Writers) | Advanced Solid Tumors | Enzymatic Screening (Requires strictly unmodified, E. coli expressed H4) |